For cervical cancer, there are certain factors that predict high risk of recurrence after a surgical resection. Studies have shown that addition of radiation therapy (and in some cases concurrent chemotherapy) would significantly reduce risk of recurrence. These high risk factors include positive surgical margins, parametrial involvement, deep stromal invasion, lymphovascular invasion, tumors larger than 4 centimeter, pelvic lymph node involvement, and periaortic lymph node involvement.
